PHRM 6200 Mitochondria and Complex Diseases

2 SCH. Lecture Topics: basic mitochondrial genetics, bioenergetics, and biogenesis; the Warburg Phenomenon and other metabolic alternations of cancer cells; mitochondrial control of apoptosis and cancer; mitochondrial ROS in cancer, mitochondrial genetic alternation in cancer; known mitochondrial diseases; laboratory techniques used in mitochondrial research. Workshop and laboratory: mitochondrial function assays; mitochondrial genetic assays to include quantification and mutation detection. Prerequisites: BMSC 6301, BMSC 6302, BMSC 6303, BMSC 6304, BMSC 6305 or permission of the instructor. Offered every Fall semester. Letter Grade