MOMG 6340 Molecular Evolutionary Genetics

3 SCH. The analysis of DNA and/or protein sequences at the gene, population, and species level has become a powerful tool for studying molecular evolution and understanding the effects of genetic change. Statistical and computational methods to effectively evaluate and interpret the data obtained from molecular level investigations have become more involved. The goal of this course is to introduce appropriate theory and methods needed to effectively analyze nucleotide and protein sequence data. Topics covered will include: measurement of sequence divergence, models of evolution, various approaches to phylogenetic evaluation and tree construction, statistical tests for detection of selection and evolutionary rates, inference of ancestral amino acid sequences, and the evolutionary significance of genetic polymorphism. Emphasis is given to practical methods of data analysis using multiple software packages designed to appropriately evaluate genetic data. Recommended Prerequisites: BMSC 5400 or equivalent, MOMG 5301 . Offered every other fall semester (odd years). Letter Grade