MOLB 6270 Drug Discovery and Design

2 SCH. Introduction to combinatorial chemistry, multi-compound based technologies, and their use in screening bioassays to discover lead compounds. Concepts of design and synthesis of compound libraries, pharmacological assay development, instrumentation, data interpretation, biological target selection, lead optimization, structure-based drug design and drug-likeness will be discussed. Prerequisite: Undergraduate general and organic chemistry or equivalent (instructor approved.)